HengShu Bio is focused on providing high-quality pharmacological and pharmacodynamic research services to its customers. With a professional technical team and advanced experimental facilities, we are committed to providing reliable data support for drug research and development through scientific and rigorous research methods, and helping the preclinical research of new drug research and development.
1. Pharmacological studies
Drug mechanism research: Through in vitro cell experiments and in vivo animal models, the target and mechanism of drug action were studied.
Drug dose-effect relationship study: to evaluate the biological effects of drugs at different doses and determine the effective dose range.
Drug interaction study: To analyze the interactions between drugs and drugs, and between drugs and physiological factors, so as to provide reference for clinical medication.
2. Pharmacodynamic evaluation
In vitro and in vivo drug efficacy screening: provide in vitro and in vivo drug efficacy screening services for gene therapy drugs, antibody drugs, cytokines, protein drugs and chemical drugs.
Disease model construction and validation: to construct a variety of disease models (such as cardiovascular and cerebrovascular disease models) and verify their effectiveness for drug efficacy evaluation.
Multi-dimensional drug efficacy evaluation: comprehensively evaluate the therapeutic effect of drugs by combining behavioral, physiological, molecular biological and other multi-dimensional indicators.
Professional technical team: A professional team with years of pharmacology and pharmacodynamic research experience, can provide customers with efficient and accurate research services.
Rich model resources: We have the ability to construct and verify a variety of disease models to ensure the reliability and repeatability of research results.
One-stop solution: from experimental design to data analysis, we provide full-process services to meet customers' diverse needs from drug screening to efficacy assessment.
HengShu BIO is committed to providing professional and efficient animal quarantine and testing services, focusing on the detection of viruses, pathogens, parasites and hematology of experimental monkeys and related animals. With an experienced research team and long-term accumulated detection experience and detection technology, we provide comprehensive quarantine and detection solutions for the related enterprises of laboratory animal production institutions and use institutions to ensure animal health and data reliability.
1. Test items
Virus quarantine: detection of laboratory monkeys common viral pathogens, such as monkeypox virus, monkeypox virus and so on.
Pathogen quarantine: detection of Mycobacterium tuberculosis, Pseudomonas aeruginosa and other common pathogens.
Parasite detection: Detection of internal parasites (such as ascaris lumbricoides) and external parasites (such as mites).
Hematological tests: blood routine, biochemical indicators, coagulation function and other tests were provided.
Other testing: according to customer needs, provide customized testing services.
2. Detection technology
ELISA detection: using enzyme-linked immunosorbent assay to detect antigens or antibodies in samples, it is suitable for a variety of viruses and pathogens.
PCR detection: Polymerase chain reaction technology is used to quickly and sensitively detect the nucleic acid of viruses and pathogens.
Professional team: We have an experienced research team with years of experience in animal quarantine and testing.
Customized service: according to customer needs, provide personalized detection program.
Rapid response: optimize the testing process to ensure rapid certification and result feedback.
Laboratory animal production institutions: Provide technical support for the health monitoring and disease prevention and control of experimental monkeys.
Scientific research institutions: Provide reliable quarantine and testing services for animal experiments to ensure the reliability of experimental data.
Enterprise research and development: pathogen screening and health assessment for new drug research and animal model construction.
Hengshu Bio provides comprehensive experimental operation services for experimental monkeys and pigs, including surgical operation, drug administration operation, sampling operation, and postoperative care. With a professional technical team and advanced experimental facilities, we can provide customers with efficient and accurate experimental operation support to ensure the smooth progress of the experimental process and the reliability of the experimental results.
1. Surgical procedures
Surgical procedures
Liver and kidney are suitable for organ function study.
Catheter implantation
Vascular catheter: suitable for long-term drug administration or blood collection.
Brain catheters: suitable for neuroscience research.
Other Procedures
To provide customized surgical services to meet different experimental needs.
Surgical facilities and equipment
Equipped with professional operating room, including shadowless light, anesthesia respiratory system, ECG monitoring system, stereotaxic instrument, suction device, electric knife and other surgical instruments.
The whole process services of preoperative preparation, intraoperative auxiliary operation and postoperative care were provided.
2.Administration procedures
Administration of oral Agents
Administration by gavage or mixed with feed/drinking water is suitable for long-term administration experiments.
Administration of drugs by injection
Subcutaneous injection: suitable for small doses of drugs.
Intramuscular injection: Suitable for drugs requiring rapid absorption.
Intraperitoneal injection: suitable for large doses of drugs.
Iv: Suitable for drugs requiring rapid onset of action.
Administration of drugs by inhalation
The drug is administered through an atomization device, which is suitable for respiratory disease research.
3. Sampling operation
Collection of blood
Blood was collected from veins (such as femoral vein, jugular vein) or arteries, suitable for pharmacokinetic studies, hematologic analysis.
Tissue biopsy
Tissue samples are collected by surgery or minimally invasive techniques, which are suitable for pathological examination and molecular biology research.
Collection of body Fluids
Cerebrospinal fluid: was collected by lumbar puncture.
Urine: collected through metabolic cages.
Saliva: collected by a dedicated device.
Advanced facilities: equipped with advanced operating rooms and experimental equipment to meet the needs of all kinds of complex operations and experimental operations.
Whole process service: from preoperative preparation to postoperative care, one-stop experimental operation service is provided to reduce the time cost and experimental risk of customers.
Experimental monkeys: Focus on the experimental manipulation of experimental monkeys and ensure the high translational value of research results by using their physiological characteristics that are highly similar to those of humans.
New drug RESEARCH and development: provide professional experimental operation support for drug pharmacokinetic, pharmacodynamic and safety research.
Disease model research: through surgery and drug administration, various disease models are constructed to support basic research.
Neuroscience research: Providing brain catheter implantation and related surgical procedures to facilitate research in the field of neuroscience.
Preclinical research: to provide experimental data that meet the requirements for new drug application at home and abroad.
HengShu Bio focuses on drug metabolism research in experimental monkeys and provides high-quality metabolic experimental services to customers at home and abroad. With rich experience in experimental monkey administration, professional technical team and advanced experimental facilities, we can provide one-stop service from experimental design to data analysis to facilitate the preclinical research of new drug development.
1. Metabolic studies in experimental monkeys
In vitro Metabolic studies
Metabolic stability of liver microsomes (experimental monkey).
Metabolic stability of hepatocytes (experimental monkey).
Identification of metabolites (microsomes, hepatocytes).
In vivo Metabolic studies
Pharmacokinetic studies of single and multiple doses (experimental monkey).
Study of drug distribution in various tissues of experimental monkeys.
Studies of drug excretion (urine, stool, blood).
Bioavailability and bioequivalence studies.
2.Experimental monkey support
Administration experience: Extensive administration experience in experimental monkeys, covering a variety of routes of administration (e.g., intravenous, oral, subcutaneous and intramuscular).
Sample collection: Able to collect samples of various tissues and organs from experimental monkeys for metabolite analysis.
Metabolic cage facility: Provision of metabolic cages required for short-term and long-term feeding and support for continuous monitoring of metabolic and behavioral indicators in experimental monkeys.
Characteristics of experimental monkeys: Focusing on metabolic studies of experimental monkeys, using their highly similar physiological and metabolic characteristics to humans to ensure the high translational value of research results.
Professional team: Experienced research team, with years of experience in experimental monkey metabolism research, can provide customers with professional experimental design and data analysis support.
One-stop service: from experimental design to data analysis, we provide full-process services to meet customers' needs from drug discovery to preclinical research.
HengShu Bio provides professional laboratory monkey dissection, sampling and sectioning services. Our experimentals have rich practical experience and are familiar with the anatomical structure of experimental monkeys, and can efficiently and accurately complete the whole process of operation from gross anatomy to tissue sectioning. The service covers anatomy, organ collection, specimen processing, section production and harmless processing, etc., to ensure the accuracy of experimental data and the high quality of samples.
1. Dissection and material harvesting
Gross anatomy
The monkeys were dissected completely, and the appearance, organ morphology and lesions were observed and recorded.
Organ collection
The heart, liver, spleen, lung, kidney and other major organs were collected accurately to ensure the integrity of samples.
Lesion tissue sampling
Tissue samples from the lesion sites were preferentially collected to ensure the accuracy of pathological analysis.
Harmless treatment
The experimental animal carcasses and wastes were treated harmlessly according to the standards to prevent pollution.
2. Specimen processing and sectioning
Fixation and preservation
The collected tissue was immediately put into the fixative to ensure the stability of the sample during transport and storage.
Production of slices
Provide high-quality tissue sectioning services, slice thickness can be customized according to experimental requirements (such as 0.5mm or 1mm), support routine pathological sections and special section needs.
Brain slice mold support
For the experimental monkey brain tissue, a special brain slice mold was provided to ensure the standardization and repeatability of the section.
3. Support by pathological analysis
Pathological section staining
We provide HE staining, special staining and other pathological section staining services to meet the observation needs of different tissue types.
Support for pathological diagnosis
Combined with pathological analysis, it supports the evaluation of drug efficacy and toxicology, and helps the interpretation of experimental results.
Professional team: the experimental personnel have years of experience in experimental monkey anatomy, are familiar with its anatomical structure, and the operation is standardized and efficient.
Full-process service: from dissection to sectioning, one-stop service is provided to reduce the time cost and experimental risk of customers.
High-quality samples: anatomical and sampling specifications were strictly followed to ensure high quality of samples and reliability of experimental data.
Harmless treatment: comply with environmental protection and animal ethics requirements to ensure the compliance of the experimental process.
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