HengShu Bio Animal Center focuses on the high standard feeding and management of experimental monkeys, and is committed to ensuring the health of animals and the reliability of experimental data through advanced software and hardware systems. With an intelligent and standardized feeding environment and refined management process as the core, we provide full-life cycle management services from young to adult monkeys, helping scientific research institutions and pharmaceutical companies to make breakthroughs in drug research and disease research. August 2024 Hengju Biological Laboratory Animal Center obtained the national authority: China National Accreditation Service for Conformity Assessment (CNAS) has the accreditation qualification for the production and use of laboratory animals in the center. CNAS management system has stricter requirements for the production and use of laboratory monkeys in the company in compliance with national and local laws, regulations and standards, ensuring the occupational health and safety of personnel, and meeting the requirements of customers and regulators. Greatly promoted the company's production and management of modernization and standardization.
1. All age groups of experimental monkeys
The laboratory animal Center has a full life cycle experimental monkey population, stable self-propagating population, and clear genetic background and pedigree. Through the production management system, the condition of each animal can be clearly understood.
2. Feeding facilities
A high standard feeding environment and strict control of pathogen contamination were provided to ensure the health of the experimental monkeys.
The animal room was equipped with advanced air purification system, temperature and humidity control equipment and independent ventilation cages to create comfortable and stable growth conditions for experimental monkeys.
3. Individualized feeding programs
The experimental animal center is equipped with a feed processing center to customize the feed formula, feeding environment and management process according to the experimental needs to meet the special requirements of different experiments on animals.
Professional experience and technical support: with years of experience in raising experimental monkeys, I am familiar with their physiological and behavioral characteristics, and can accurately meet the experimental needs.
Whole life cycle management: To ensure the health and stability of experimental monkeys at different stages of growth, we provide a whole life cycle management service from juvenile to adult.
Data reliability: through intelligent monitoring and data analysis system, to ensure the accuracy and repeatability of experimental data, to provide a solid foundation for scientific research.
Drug safety evaluation: Provide standardized laboratory monkey feeding and health monitoring services for new drug research and development to ensure the reliability of experimental data.
Neuroscience research: Support for behavioral and neurophysiological research by providing stable experimental monkey models and behavioral observation facilities.
Spontaneous animal model screening: Provide spontaneous experimental monkey model screening service to assist drug research on geriatric
The Animal Model Development platform is a cutting-edge scientific research platform focusing on the construction and verification of experimental monkey disease models. We are committed to providing high-quality experimental monkey models for translational research through advanced gene editing technology and accurate disease simulation. The platform relies on international leading scientific research facilities and professional teams, combined with the physiological and genetic characteristics of experimental monkeys and humans, to ensure the reliability and translational value of the model in drug development, disease mechanism research and gene function verification. With one-stop service as the core, we provide efficient and accurate solutions for global scientific research institutions and pharmaceutical companies from model design to validation.
1. Rich experience and cutting-edge technology application
Application of cutting-edge technology: CRISPR/Cas9 and other advanced gene editing technologies are used to achieve precise gene modification and functional regulation.
Customized services: According to customer needs, we design and construct experimental monkey models with specific gene mutations or knockout to meet personalized research needs.
High success rate: With optimized editing process and strict quality control, the success rate of gene editing and the stability of the model are ensured.
2. Systematic construction of disease models
Multi-domain coverage: developing disease models covering cardiovascular diseases, neurological diseases (Parkinson's disease, Alzheimer's disease), and metabolic diseases (diabetes, obesity).
Accurate simulation: By simulating the pathophysiological processes of human diseases, the model ensures a high degree of behavioral, physiological and molecular consistency.
3. Model validation service
Multi-dimensional validation: the validity and reliability of the model were comprehensively evaluated by combining behavioral tests, imaging examinations (such as MRI and PET), pathological analysis and molecular biological detection.
Data-driven: Provide detailed validation reports, including comparative analysis of key indicators, to provide scientific basis for follow-up research.
Spontaneous model screening: Based on the large population resources of full-cycle experimental monkeys, we provide various spontaneous model screening research services.
One-stop service: from model design, gene editing, disease induction to validation and evaluation, we provide a whole-process solution to save time and cost.
Professional team and facilities: We have an interdisciplinary team composed of geneticists, veterinarians and biomedical engineers, equipped with international advanced experimental facilities and testing equipment.
Customized solutions: According to customer needs, provide personalized model development solutions to meet different research directions and application scenarios.
Drug development: Provide reliable animal model support for new drug research and development, accelerate drug screening and preclinical research.
Disease mechanism research: to explore the molecular mechanism of the occurrence and development of diseases, and provide theoretical basis for clinical treatment.
Gene function study: to verify the role of genes in physiological and pathological processes and explore the feasibility of gene therapy.
Personalized medicine research: developing personalized treatment regimens for specific gene mutations or disease phenotypes to promote the development of precision medicine.
The platform focuses on the in-depth research of experimental monkeys at the gene, protein and cellular levels, and is committed to providing accurate and efficient technical support for life science research through cutting-edge molecular biology technology and cell manipulation methods. Combined with the highly similar genomic characteristics of experimental monkeys and humans, the platform supports comprehensive solutions from basic research to preclinical applications, and helps researchers make breakthroughs in the fields of gene function, drug target screening and cell therapy.
1. Gene editing and functional studies
It is equipped with advanced gene editing platforms and assisted reproduction platforms to achieve accurate gene modification and functional regulation.
We provide gene knockout, knock-in and mutation model construction services to support gene function verification and disease model development.
2. Proteomics and metabolomics analysis
Advanced equipment such as high-resolution mass spectrometry and liquid chromatography were used for proteomics and metabolomics analysis.
It provides protein expression profiling, metabolite quantitative analysis and pathway analysis services to reveal the molecular changes in experimental monkeys under physiological and pathological conditions.
3. Cell transplantation and therapy research
We support stem cell therapy, immune cell therapy and other research, and provide whole-process services of cell isolation, culture, labeling and transplantation.
Equipped with advanced cell manipulation equipment and real-time monitoring system to ensure the safety and efficacy of cell therapy.
Highly translational value: The genome of experimental monkeys is highly homologous to that of humans, and the research results greatly facilitate the research of human diseases and accelerate the translation process from laboratory to clinical.
One-stop service: The whole process service from sample collection, experimental operation to data analysis is provided to meet the diverse needs of researchers.
Professional team and technical support: We have experienced molecular biology and cell biology teams, combined with advanced software and hardware systems to ensure the efficiency and accuracy of experiments.
Applicable scenarios
Gene function research: using gene editing technology to study the function of specific genes in physiological and pathological processes.
Drug target screening: combining proteomics and metabolomics analysis to identify potential drug targets and accelerate the development of new drugs.
Cell therapy research: Support cutting-edge research such as stem cell therapy and immune cell therapy, and explore the safety and efficacy of cell therapy.
The platform focuses on the behavioral and neuroscience research of experimental monkeys, and is committed to providing comprehensive support for high-level brain science research through cutting-edge behavioral testing, neuroelectrophysiological recording and neuroimaging analysis technology. The platform combines the highly similar nervous systems of experimental monkeys and humans, supports the translation from basic research to preclinical applications, and facilitates breakthrough progress in the field of neuroscience.
1. Behavioral tests
Provide comprehensive behavioral testing services, covering cognitive function tests (e.g., memory, learning), mood tests (e.g., anxiety, depression) and social behavior tests.
It is equipped with an advanced behavioral analysis system to support the study of natural behavior in a free-moving environment and reveal the neural basis of complex social behavior in primates.
2. Neuroelectrophysiological recording
Electroencephalogram (EEG) and deep brain stimulation (DBS) were used to record and analyze neuronal activity in real time.
It supports wireless recording technology and enables dynamic monitoring of neurons under free-moving conditions to reveal the neural coding mechanism of natural behaviors.
3. Neuroimaging analysis
Combined with MRI, fMRI and other advanced imaging techniques, to study the brain structure and function of experimental monkeys.
It provides multi-modal image analysis from macro to micro to support the construction of brain disease models and neural mechanism research.
High translational value: The nervous system of experimental monkeys is highly similar to that of humans, and the results can be directly applied to human neuroscience research.
Full-process support: provide full-process services from experimental design, data collection to data analysis to meet different research needs.
Advanced technologies: Combining wireless recording, computer vision, and behavioral analysis techniques to support the study of natural behavior in free-moving environments.
Neurological disease research: To study the pathogenesis of neurodegenerative diseases and psychiatric diseases through behavioral and neuroimaging analysis.
Evaluation of psychotropic drugs: to evaluate the effects of drugs on cognitive function, mood, and behavior, and to support new drug research and development.
Brain-computer interface (BCI) research: Combining neuroelectrophysiological recordings and behavioral tests, to explore the application of brain-computer interface technology.
The platform focuses on providing high-resolution, multi-dimensional imaging detection and analysis services for experimental monkeys, and is committed to providing accurate and dynamic imaging solutions for researchers through advanced software and hardware systems. Combined with the physiological characteristics of experimental monkeys and research needs, the platform optimizes imaging parameters and equipment configuration to support a full range of imaging support from basic research to preclinical application.
Customized imaging protocol: According to the body size and physiological characteristics of the experimental monkeys, the imaging parameters and equipment configuration were optimized to ensure the accuracy of imaging effect.
Dynamic data support: support long-term follow-up research, provide dynamic data support, and help to study the progress of the disease and the effect of treatment.
Multi-dimensional data analysis: Combined with advanced three-dimensional reconstruction and quantitative analysis technology, it provides comprehensive imaging data support.
Tumor research: Real-time monitoring of tumor growth, metastasis, and response to therapy by dynamic imaging techniques.
Neurological disease research: The use of high-resolution imaging equipment, to observe changes in the structure and function of the nervous system.
Cardiovascular disease research: real-time monitoring of dynamic changes in the cardiovascular system, assessment of disease progression and drug efficacy.
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